![]() ![]() For another, pre-clinical and small-scale clinical investigations have provided validated information on the efficacy of HBOT against aging from various aspects. Interestingly, the therapeutic targets of HBOT overlap considerably with those of aging and age-related diseases. For one thing, an extensive body of basic research has expanded our mechanistic understanding of HBOT. In fact, despite the conventional wisdom that excessive oxygen accelerates aging, appropriate HBOT protocols without exceeding the toxicity threshold have shown great promise against aging. The noninvasive nature, favorable safety profile, and common clinical application of HBOT make it a competitive candidate for several new indications, one of them being aging and age-related diseases. Hyperbaric oxygen therapy (HBOT), a technique through which 100% oxygen is provided at a pressure higher than one atmosphere absolute (ATA), has become a well-established treatment modality for multiple conditions. Management with HBO2 for DKD was associated with decreased excretion urinary albumin, improved GFR and clinical stage of patients in stages 3 and 4 of kidney damage unlike those receiving ambient air. The patients in the control group showed a UACR mean of 2784.5 ± 2128.6 mg/g and 2861.4 ± 2424.2 mg/g at baseline and at the end of the study, respectively (p=0.82). ![]() ![]() Urinary albumin/creatinine (UACR) mean values prior to HBO2 were 1452.9 ± 644.3 mg/g and decreased to 876.1 ± 504.0 mg/g at the end of the study (p=0.06). A descriptive, inferential and clinical efficacy analysis was performed. Estimated glomerular filtration rate, urine albumin:creatinine ratio calculation and clinical stage stratification were made prior to and after HBO2 administration. Twenty sessions of HBO2 or ambient air in a hyperbaric chamber were administered. The objective of this study was to quantify the efficacy of adjuvant HBO2 to increase the glomerular filtration rate and urinary albumin excretion in diabetic patients, as well as determine its effectiveness to modify the clinical course of DKD.Īn experimental study was performed on patients with stage 3 and 4 DKD. Hyperbaric oxygen (HBO2) therapy will increase the partial pressure of oxygen (PaO2) and may improve cell repair processes, which can lead to better renal function. Diabetic kidney disease (DKD) is the most common microvascular chronic complication of diabetes mellitus. ![]()
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